Welcome to the 2nd conference dedicated to soft mist inhalers (SMI). Learn to make, develop, use, file, launch Soft Mist Inhalers, and their place in an inhaled therapy portfolio.

Soft Mist Inhalers are slated to capture 50% of the portable inhaler market. They are THE inhaler device choice for deep lung deposition, for local and systemic action with a low carbon footprint. Soft Mist Inhalers are versatile, user-friendly, easy to formulate and easily implemented in an inhaler portfolio. Soft Mist Inhalers love biologics therapies.

About

SMI.London 2024 will carry on the conversation on Soft Mist Inhalers started in 2023.

The conference will illustrate how Soft Mist Inhalers are taking their place alongside other inhalers and what benefits their bring.

This year the one-day meeting will explore:

  • applications of Soft Mist Inhalers with new therapies and novel formulations,

  • advanced methods to probe Soft Mist Inhalers,

  • Soft  Mist Inhaler aerosol deposition and its impact on therapies,

  • and recent developments in tools to make and study Sof Mist Inhalers.

Schedule

8am — 5pm
Speakers Include

Download PDF Programme

8:00
Registration, refreshments and networking

Chair of the session: Dr. Jag Shur, Founder, Theela Science Ltd



9:00
Welcome Back To SMI.London: What Happened Over The Last 12 months?
Dr. Philippe Rogueda, Chief Business Officer, Merxin Ltd

  • A quick review of the scientific literature

  • A survey of markets dynamics

  • What is the latest gossip?

9:45
Plenary Lecture: Soft Mist Inhalers, A Comparison With Nebulizers
Dr. Darragh Murnane, Professor of Pharmaceutics, University of Hertfordshire

  • Aerosolization from nebulizers and soft mist inhalers – what are the formulation approaches?

  • Lung deposition using aqueous droplet aerosols

  • Dose delivery characteristics and the benefits of device efficiency not just total dose

  • Preferences and user concerns

  • Suitability for therapies of the future

10:30
Coffee break and networking

11:00
Administration Of Soft Mist Via Respiratory Supports - Nasal Delivery
Dr. Wei-Ren Ke, Assistant Professor, National Taiwan University School of Pharmacy

  • The utilization of soft mist inhalers (SMI) has significantly expanded, accompanied by a growing demand for their use in respiratory support modalities, including High-Flow Nasal Cannula (HFNC) and mechanical ventilators.

  • While both pressurized metered-dose inhalers and SMIs are categorized as metered-dose devices, their distinct spray characteristics, such as velocity and duration, differentiate their application in respiratory support scenarios.

  • The administration of soft mist through invasive mechanical ventilation is viable; optimally, the soft mist should be delivered 15 cm from the Y-piece and actuated at the conclusion of the expiration phase of inspiration.

  • The usage of HFNC has significantly risen since the COVID-19 pandemic. However, the lack of commercially available adapters for SMI use during HFNC therapy restricts treatment options for inpatients.

  • The optimal adapter connecting the SMI and HFNC was developed and assessed using in vitro and in silico methods. Results showed that reducing HFNC flow rates significantly improved soft mist delivery efficiency.

11:30
Test Method For A Check Valve For High Pressure Atomization In A Soft Mist Inhaler
Mr. Andre Widmann, Development Engineer Device Services, Harro Höfliger

  • Functionally relevant tasks of micropump and check valve to enable medication administration.

  • Root cause for malfunction of device dosage delivery.

  • Test methodology to allow a 100% test of the valve function on a subassembly of the SMI.

  • Dedicated test setup to control flow and blocking function of the high-pressure check valve as well as result interpretation of time, flow and pressure.

 

12:00
What’s Your Target? Customizing Lung Delivery With Electrospray
Dr. Mehmet Uzumcu, Chief Scientific and Technology Officer, Gilbert

  • What is electrospray (EHDA) and how does it work?

  • Critical parameters for controlling and optimizing performance?

  • What unique benefits can electrospray offer?

  • Where can it be best applied?

12:30 
Lunch, exhibition, and networking

Chair of the session: Mr Chris Vernall, Commercial Director, Intertek

14:00
Characterizing Plume Development Using Tandem Aerodynamic Particle Sizers
Mr. Lance Jiang, Aerosol CDT PhD researcher, University of Bristol

  • Plume generation is a dynamic process; the tandem aerodynamic particle sizer (TAPS) method can aid in understanding the plume development.

  • Raising relative humidity could cause particles to grow and potentially alter the deposition profile.

  • Single particle characterization techniques can provide valuable information that can be translated into understanding plume dynamics.

  • The radial growth factor ratio can be used to quantify the magnitude of change in size for single particles and size distribution of plumes at varied conditions.

  • An increase in ethanol concentration leads to changes in the overall size distribution and plume development patterns.

 

14:15
‘Whole Aerosol’ Approach for Aqueous Droplet Inhalations
Mr. Aurelien Martin, PhD Student, University of Hertfordshire

  • Introduction to Particle Size Distribution (PSD).

  • Quick review of current regulatory guidance.

  • Impact of temperature and relative humidity on PSD via Laser Diffraction.

  • Impact of temperature and relative humidity on PSD via Impaction.

 

14:30
The Lifetime Of A Droplet: The Impact Of Droplet Microphysics & Aerosolisation Methods
Dr. Dan Hardy, Founder, Microsol Ltd

  • Comparisons of the key timescales relevant to SMI droplets and drug delivery.

  • Exploration of the microphysical processes occurring within droplets.

  • Discussion the microphysics involved in delivering biologicals via droplets.

  • Comparisons of aerosolisation methods and devices.

15:00 
Tea break and networking

Chair of session: Dr. Jenny Lam, Associate Professor Pharmaceutics, University College London

15:30
Transforming Respiratory Care With Soft Mist Biologics
Dr. Daniela Traini, Professor, Macquarie Medical School, Macquarie University

  • Overview of the current inhaled biologics market, and the pipeline of inhaled therapies options.

  • Review of recent trials of inhaled biologics in SMIs

  • Device considerations for inhaled biologics

  • The suitability of soft mist inhalers for delivering biologics to the lungs.

 

16:00
Oldies but Goldies: Repurposing Heparin for Lung Diseases
Dr. Ayca Yıldız-Peköz, Professor, Department of Pharmaceutical Technology, Istanbul University

  • Repurposing of Heparin for viral lung diseases.

  • Demonstration fo antiviral indication of Heparin .

  • Review of clinical studies of Heparin in SMI.

  • Development of animal models for the new generation SMIs.

  • How SMIs enable lower dose higher efficacy of antivirals.

16:30
Final remarks & panel discussion

17:00 
Close of the day

Venue

PULLMAN LONDON ST PANCRAS

100-110 EUSTON ROAD

London

NW1 2AJ

UK

25 June 2024

SMI.London 2024 will take place at the Shaw Theatre located in King’s Cross, within the contemporary stylish and cosmopolitan Pullman London St Pancras Hotel.

Register

Registration for SMI.London 2024 is now open.

Registration fee is £695.00 (excl. UK VAT) per person.

Registration fee includes:

  • Full conference attendance to lectures, networking sessions and exhibition.

  • Conference slides post conference, dependant on permission granted by Speakers.

  • Full day catering.

Note: Discounts are available for groups of more than 5 registrants from the same institution, and for members of academic institutions. Please email info@smi.london for more information.

Credit card payments are accepted online via Stripe. If you wish to pay via bank transfer, please ensure that payment is received within 7 days of your invoice date.

By registering you consent for your information to be shared with the event partners. It is not possible to register without agreeing to this consent.

Exhibit

Would you like to be part of the  SMI.London 2024 exhibition?

A limited number of table-top exhibition options are available. Exhibition benefits include:

  • Physical presence at the event

  • Table-top or space for exhibiting your services and products

  • 2 free registrations for your staff

  • Full participants’ list post event

  • Full listing on the conference website

  • Acknowledgement on social media and SMI.London 2024 communications

The exhibition fee is £3,000 (excl. UK VAT). Please email below to book your space.